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Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty
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《医学前沿(英文)》 2018年 第12卷 第2期 页码 174-181 doi: 10.1007/s11684-017-0544-5
The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) has been recently documented. In this study, 280 girls diagnosed with ICPP and 188 normal puberty control girls of similar ages were enrolled and retrospectively studied. The ICPP group had significantly lower serum 25-hydroxyvitamin D (25[OH]D) levels than the control group. Furthermore, a nonlinear relationship was found between serum 25[OH]D and ICPP, and a cut-off point for serum 25[OH]D was found at 31.8 ng/ml for ICPP with and without adjusting the different confounding factors. Girls with serum 25[OH]D≥31.8 ng/ml had a lower odds ratio (unadjusted: OR 0.36, 95% CI 0.15 to 0.83, <0.05; height and weight adjusted: OR 0.44, 95% CI 0.18 to 1.08, = 0.072; BMI adjusted: OR 0.36, 95% CI 0.16 to 0.84, <0.05). The ICPP subjects with 25[OH]D deficiency had a higher body mass index (BMI) than the subjects from the two other subgroups. Correlation analysis showed that vitamin D level is correlated with BMI and some metabolic parameters in the ICPP group. Our study suggested that vitamin D status may be associated with ICPP risk and may have a threshold effect on ICPP.
关键词: idiopathic central precocious puberty threshold effects vitamin D status
Hui Wan,Yu Xia,Jianghua Li,Zhen Kang,Jingwen Zhou
《化学科学与工程前沿(英文)》 2017年 第11卷 第1期 页码 72-88 doi: 10.1007/s11705-016-1580-4
关键词: 2D-DIGE pqqB pyrroloquinoline quinone RNA-Seq Vitamin C
八步连续流全合成维生素B1工艺研究 Article
姜梅芬, 刘敏杰, 李伟剑, 夏应奇, 陈芬儿
《工程(英文)》 2024年 第32卷 第1期 页码 230-239 doi: 10.1016/j.eng.2023.01.016
维生素B1作为一种抗利尿和抗氧化剂被广泛应用于医疗保健和食品行业,以维持神经传导、心脏和胃肠道的正常功能。本研究报道了由市售2-氰基乙酰胺进行的维生素B1的八步连续流全合成工艺。本研究提出的连续流工艺基于化学、工程和设备设计的创新基础,与间歇釜式工艺相比,生产的性能和安全性均有所提高。本文使用各种微通道流反应器、微混合器、连续分离设备和连续过滤器等装置,对连续流合成工艺中的问题和挑战进行了精确的研究和控制,包括混合、意外堵塞、溶剂切换、放热反应和避免副反应等。维生素B1全合成的连续流工艺总停留时间约为3.5小时,产品纯度高,分离产率为47.7%。该八步连续流动技术方案至少涉及绿色化学的六个关键准则。因此,连续流技术的应用对于提高生产安全性、减少废物污染,尤其是提高批量操作的生产效率至关重要。
Current status and prospects of reliability systems engineering in China
《工程管理前沿(英文)》 2021年 第8卷 第4期 页码 492-502 doi: 10.1007/s42524-021-0172-2
关键词: reliability effectiveness model-based systems engineering reliability systems engineering
Present status and progress of neoadjuvant chemoradiotherapy for esophageal cancer
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《医学前沿(英文)》 2013年 第7卷 第2期 页码 172-179 doi: 10.1007/s11684-013-0268-0
Trimodality based on neoadjuvant chemoradiotherapy (nCRT) followed by surgery is gaining popularity as a treatment strategy for locally advanced esophageal cancer. In this review, we summarize the role of nCRT and the recommended nCRT regimens based on clinical trials and meta-analyses. We analyze the relationship of nCRT with pathologic complete response (pCR) and then identify potential predictive markers of response. Compared with surgery alone and neoadjuvant chemotherapy followed by surgery, trimodality provides longer survival and has the advantage of local control compared with definitive chemoradiotherapy. The standard regimen is a platinum-based regimen with a radiation dose range of 41.4–50.4βGy by conventional fractionation. Evidence shows that patients with pCR tend to live longer than non-responders, indicating that pCR is a significant prognostic factor for patients with esophageal cancer. Individualized medicine requires predictive markers of individual patients based on their own genes. Currently, no definite marker is proved to be sufficiently sensitive and specific for use in clinical practice, although 18-fluorodeoxyglucose positron emission tomography shows promise in predicting response to nCRT.
Wenqian CAI,Wei MENG,Lusan LIU,Kuixuan LIN
《环境科学与工程前沿(英文)》 2014年 第8卷 第5期 页码 737-746 doi: 10.1007/s11783-013-0617-x
关键词: AZTI’s Marine Biotic Index Shannon-Wiener Index W-statistic ecological status coastal system Bohai Bay (China)
EGG PRODUCTION IN CHINA: CURRENT STATUS AND OUTLOOK
《农业科学与工程前沿(英文)》 2021年 第8卷 第1期 页码 25-34
• China is now the largest egg production country worldwide
• Egg production in China is characterized by diversity in several aspects
• China is now capable of breeding new varieties, with more than 50% of the market share
• Policies have been implemented to ensure sustainable development of egg production
• Integrating crop-chicken-vegetable production system is established
Eggs are one of the most nutritious and affordable animal products worldwide. From 1985, egg production in China has retained the leading place in the world. A total of 33 Mt of eggs were produced in 2019 representing ˃ 40% of the world total production. Egg production in China is characterized by diversity in several aspects, including layer breeds, products and production systems. New breeds and synthetic lines are developed to improve the genetic potentials of egg production and feed efficiency of layers. In the past, layer farms were run mostly by small households with 100 to 1000 layers per farm. Over the past decades, egg production in China has developed toward standardization and expansion of production systems, and many of these modern intensive farms raise millions of layers. Although the Chinese egg products maintain strong competitiveness over other animal products and imported egg products, the egg industry will grow at a slower pace compared to the past. Chinese consumers are more concerned about the quality and safety of eggs and egg products, as well as the environmental issues related to animal production, which presents challenges for the Chinese egg industry.
HIGH-PERFORMANCE COMPUTATION AND ARTIFICIAL INTELLIGENCE IN PESTICIDE DISCOVERY: STATUS AND OUTLOOK
《农业科学与工程前沿(英文)》 2022年 第9卷 第1期 页码 150-154 doi: 10.15302/J-FASE-2021419
Catalytic conversion of biomass-derived compounds to various amino acids: status and perspectives
《化学科学与工程前沿(英文)》 2023年 第17卷 第7期 页码 817-829 doi: 10.1007/s11705-022-2254-z
关键词: biomass amino acids chitin nitrogen-containing compounds lignocellulose
Jianping AN, Xiaofei WANG, Chunxiang YOU, Yujin HAO
《农业科学与工程前沿(英文)》 页码 231-235 doi: 10.15302/J-FASE-2020367
EGG PRODUCTION IN CHINA: CURRENT STATUS AND OUTLOOK
Ning YANG
《农业科学与工程前沿(英文)》 2021年 第8卷 第1期 页码 25-34 doi: 10.15302/J-FASE-2020363
Advancing ion-exchange membranes to ion-selective membranes: principles, status, and opportunities
《环境科学与工程前沿(英文)》 2023年 第17卷 第2期 doi: 10.1007/s11783-023-1625-0
● IEM ion/ion selectivities of charge, valence, & specific ion are critically assessed.
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《医学前沿(英文)》 2011年 第5卷 第1期 页码 45-52 doi: 10.1007/s11684-011-0117-y
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia. In past decades, intensive studies on the biology and treatment of this disease have resulted in a remarkably thorough understanding of its pathogenesis and improvement of treatment outcomes. In particular, the introduction of all-trans retinoic acid to conventional chemotherapy improved dramatically the remission and survival rates of APL patients and consequently became the major treatment modality for it. In the last decade, the groundbreaking development of arsenic further improved the survival rate of APL patients. As the most active agent in APL, arsenic directly degrades the PML-RARα fusion transcript, leading to the differentiation and apoptosis of leukemia cells and the potential eradication of APL leukemia-initiating cells (LICs), thus making the disease a potentially curable type of leukemia. More notably, the recent development of oral arsenic compounds may further enhance not only clinical outcomes but also the convenience of patients, which may dramatically change the APL clinical scenario in the near future.
关键词: acute promyelocytic leukemia arsenic all-trans retinoic acid survival
使用2D、3D和4D增材制造材料开发生物植入物 Review
刘果, 何云虎, 刘朋超, 陈舟, 陈绪梁, 万镭, 李莹, 吕坚
《工程(英文)》 2020年 第6卷 第11期 页码 1232-1243 doi: 10.1016/j.eng.2020.04.015
Energy and environment in Chinese rural housing: Current status and future perspective
Xudong YANG, Yi JIANG, Ming YANG, Ming SHAN,
《能源前沿(英文)》 2010年 第4卷 第1期 页码 35-46 doi: 10.1007/s11708-010-0001-5
标题 作者 时间 类型 操作
Identification of transporter proteins for PQQ-secretion pathways by transcriptomics and proteomics analysis in
Hui Wan,Yu Xia,Jianghua Li,Zhen Kang,Jingwen Zhou
期刊论文
Evaluation of the ecological status with benthic indices in the coastal system: the case of Bohai Bay
Wenqian CAI,Wei MENG,Lusan LIU,Kuixuan LIN
期刊论文
HIGH-PERFORMANCE COMPUTATION AND ARTIFICIAL INTELLIGENCE IN PESTICIDE DISCOVERY: STATUS AND OUTLOOK
期刊论文
Catalytic conversion of biomass-derived compounds to various amino acids: status and perspectives
期刊论文
THE ANTHOCYANIN BIOSYNTHETIC REGULATOR MDMYB1 POSITIVELY REGULATES ASCORBIC ACID BIOSYNTHESIS IN APPLE
Jianping AN, Xiaofei WANG, Chunxiang YOU, Yujin HAO
期刊论文
Advancing ion-exchange membranes to ion-selective membranes: principles, status, and opportunities
期刊论文
Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research
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期刊论文